Tough break on this one...
Depomed Drops As Test Results Disappoint
Associated Press 07.10.07, 12:49 PM ET
Depomed Inc. shares lost more than half their value Tuesday morning after the specialty drugmaker reported disappointing results in a late-stage clinical trial of its key drug candidate.
The pill, Gabapentin GR, failed to significantly reduce pain when compared with placebo in patients with postherpetic neuralgia, a persistent pain condition caused by nerve damage after a shingles infection.
The drug is an extended-release version of gabapentin, which is already approved by the Food and Drug Administration to treat PHN. Depomed is testing the extended-release drug as a treatment for diabetic peripheral neuropathy and other conditions.
The Phase III trial results prompted at least three analysts to cut their ratings and remove their price targets on the Menlo Park, Calif.-based company.
"Until we gain further visibility on the future of the Gabapentin development program, we advise that investors stay on the sidelines," wrote Thomas Weisel analyst Donald Ellis in a note to clients Tuesday morning.
Ellis lowered his rating to "Market Weight" from "Overweight" and suspended his price target.
Shares of Depomed plummeted in morning trading, falling $2.83, or 57 percent, to $2.10 at midday. Earlier in the session, the stock traded as low as $1.83, its lowest point in more than four years.
CIBC World Markets analyst Elliot Wilbur cut his rating to "Sector Performer" from "Sector Outperformer."
"These results were unexpected, given the low risk associated with new formulation and the encouraging Phase II results," Wilbur wrote. The analyst estimates that the opportunity from gabapentin accounts for about two-thirds of Depomed's valuation.
Oppenheimer & Co. analyst Scott Henry had a similar assessment of the company.
"Gabapentin GR was $6 of our $9 price target and the primary reason to own Depomed," he wrote.
Henry lowered his outlook to "Neutral" from "Buy."