I have the benefit of working in LV and am out there 3 or 4 times a month, so feel compelled to add my $0.02
There is so many entertainment oportunities in LV and it is impossible to do them all in one weekend. Everyone's recommendations above are good ones (have done them all).
Much depends on what your priorities are; gambling, clubbing, strippers, eating, etc. so I'll try to hit briefly on all of them. Another big one is whether you are single or with your girl. Since you are going with your friends, I'll focus on the "single guy" scenario.
I have spent many superbowl weekends out in LV, but now avoid it because the normal 2:1 ratio of guy to good looking girl is tripled at least. Too much testosterone for my tastes. This can be great if you are out with your buddies and really don't give a shit...but if you bring your girl out there, she is going to get hit on, constantly. The good thing about all the guys is that Las Vegas becomes HOME BASE for strippers around the country. The LV airport is a great place to see hot chicks, especially on the thursday before and the Monday and Tuesday after.
GAMBLING: If your motivation is winning, strongly recommend going downtown. I always have better luck downtown. Try the Californian, a small casino catering to Pacific Rim countries. There is definitely a different clientele downtown compared to the strip. So if you want some eye-candy while you gamble, I highly reccomend the Hard Rock, The Palms, Mandalay Bay, and Ceasars.
CLUBBING: All of the big clubs will be packed SB Weekend. I highly suggest you go VIP if you intend on clubbing. You simply go to the front of the line and tell the bouncer you want to buy a bottle (or bottles). You get to sit in the VIP area, and get catered service by a hot waitress. Now a bottle is going to cost some major $$$$, but the reality is that between you and your friend (s), you will spend close to that amount on entry ($20 or more per) and drinks ($10 per). Considering the time in line and waiting for watered-down drinks....It is so worth the $$$. An added benefit is that chicks will be all over you. Sit at your seat and grab one walking by or go find a girl and invite her to sit with you. Guaranteed success. At some clubs, the bouncers behind the velvet rope will work for you. I've had bouncers go get girls for us and also "remove" girls that were wasting our time. But don't forget to tip everyone.
As far as good clubs and/or lounges, I prefer hip hop over techno/trance so prefer clubs that at least mix it up. The Palms (Rain and Ghost Bar). Circle bar and side bar at Hard Rock will be going off (lots of guys), but the club there (Babies) is pretty young and techno. Rum Jungle at Mandalay Bay used to be good, but I've noticed a sharp decrease in talent. Studio 54 always has nice looking women. I, too, like a previous poster, prefer to start the night at lounges. V-Bar at venetian is good...Shadow at Ceasars, Ghost Bar...Tabu at MGM, Voodoo Lounge at Rio. I've heard good things about Light and Venus, but have never been.
STRIPPERS: The best are (imo) Crazy Horse II, Club Paradise, Saphire (new entry), and Olympic Garden. The best looking women, hands down, are at Club Paradise, but I hate the place. You get seated and can't walk around, so the girls come to you. I like to roam, and the best place to roam is Crazy Horse Too. Tons of beautiful girls, most with great attitudes. Saphire is huge and I've only been once, and it was really good too. Olympic Garden is hit or miss, the girls are getting a little too "worn" for my tastes. But for sheer debauchery (and a blow job too), go to Spearmint Rhino at about 5 or 6 am. Can't really say the girl is going to be all that, but if you really have to bust a nut...
There are a number of of after hour clubs(4 am or later), but Drai's is probably the most well-known and best of the bunch.
And for a final recommendation, stay Monday Night and go to the Foundation Room at Mandalay Bay. This private club is only open Monday nights to the public. This is a great place to see the country's best strippers (and hottest local cocktail waitresses) out in a club, as many stay after the busy weekend to avoid the airport and enjoy a night out partying. Also heard that House of Blues on Sunday night is going off now...same scenario.
WHORES: Nothing funnier to me than seeing a girl sitting in front of a slot machine (not playing) with her cell phone to her ear. Mandalay Bay, for sure. The Palms has their fair share now too. Another gathering spot is The Rio...go to the back bar just to the right of the main entrance at about 3:00 AM. They are cute and they are all working.
DINING: I prefer good meals, so I stay away from Buffets, because they just make me feel like shit (and shitting) afterwards. There are more great restaurants in Las Vegas than anywhere in the world. My personal faves are Little Budha and 9 at Palms (check out the women at the bars), anything in the Ceasar Shops, MGM also has several great restaurants. For late night dining (4 AM), the cafe at Hard Rock is always good. Some good choices off strip too (Hamada, Morton's,)
SHOWS: Blue Man Group or Circ du sulait (sp?).
Well, I could go on but that's enough for now. I hope you have a great time and am sure that no matter what you and your friends do, you will have a great trip.
And as far as the game itself...it's always been an afterthought for me after a weekend of partying and usually watch it in my hotel room half asleep or getting busy.