8:20 p.m. ET: Buffalo Bills at New Orleans Saints
The Bills (6-4 SU, 5-4-1 ATS) are only 2-3 over their last five games and just got crushed by the Colts 41-15, losing outright as 7-point home favorites. The Saints (5-5 SU, 5-5 ATS) are also struggling, mired in a 3-game losing skid. New Orleans just got rolled by Philadelphia 40-29, failing to cover as 3-point road dogs. This line opened with Buffalo listed as a 4.5-point road favorite. The public is hammering the Bills, driving Buffalo up to the key number of -6. Some shops are even heading to 6.5. At this point, the Saints possess some buy-low inflated line value at 6.5. Sean Payton is 4-1 ATS as a dog this season and 45-26 ATS (63%) in his career. Primetime dogs are 22-11 ATS (67%) this season. Wiseguys also hit the under, dropping the total from 46.5 to 45. If the total is 45 or less, the under is 32-20 (62%) this season. This is also a non-conference under match (68%).