Holders get the same protection as kickers or punters. If a guy punts the ball, and gets ran over, whether the defender meant to or not, that is personal foul roughing. If he gets PUSHED into the guy, thats a little different. But Adrian wasnt pushed. He was in control of his body, and it's his own fault, "slipped" or otherwise. He took that route, he missed the block, and he ran over the holder. That holder literally got run over. It wasn't completely intentional, but that's not really the point. It's like going for a block, and just missing the ball, and accidentally running over the kicker or punter. That is a no brainer penalty and a defenseless holder sitting on the ground gets the same protection.
The Ben roughing was horrible. Then again, if you consider the circumstances of the game, lots of chirping, lots of scuffles, etc you can't blame the refs for trying to take control of the game, starting with the QB. I don't agree with the call, Ben was moving in the pocket, the ball was out for a second or two, and I thought the hit was clean - no helmet, involved, etc.....but I could see the call being defended that they were going to call any questionable roughing penalties, especially on defenseless players.