If there's enough variance to the posted Game line, then I'll often place a 1H wager as well. But not always. Sometimes might just make a 2u or max 3u wager on a side for the Game line only. So much depends on each team in a contest, their respective depth, FT% shooting, etc.
1H's should be treated as their own animal. Personally have found it helpful to track team performances for the 1st 10 min, entire 1H, 1st 10min of 2H, and entire 2H. Divide into four 10 min quarters including pace rates. Can help even when you have no wagers prior to a game because a 2H opportunity may arise. GL