Don't overthink this one guys. Despite an earlier loss to the Panthers at home, SF is the better team, with better athletes and more experience. Don't buy into playing this trendy Carolina team at home. It's a mistake.
Crabtree did not play in the 10-9 Carolina win and Davis left after the 2Q. These two will open up the entire field and provide big-time targets for Kaep all day long. Coupled with the fact that SF has won 7 straight, there isn't a hotter or more confident bunch on both offense and defense than the 49ers.
For Carolina, S. Smith is questionable and if he goes, he won't be 100%. I expect SF to force two picks from Newton as SF will get up early and Newton will press. Simply put, I don't trust Newton especially without Smith in this type of game.
If you're in a hole right now, take the 49ers and be confident they win by 7 or more. They will dominate the line of scrimmage and time of possession and be poised for a matchup in Seattle next Sunday.
Let it rip!