Yes, I would focus on fewer national leagues. I play England, Italy, Ireland, Brazil and Colombia. I play those five leagues because coverage is in English or I can easily translate. I play England and Italy because they are major and I enjoy the play (plus, I'm Italian heritage). I play Ireland because of the Friday afternoon schedule. I play Brazil because they are the main South American league, and Colombia because I like the style and because they were on Gol TV. I may drop Colombia if Mexico starts getting regular television coverage in America and/or gets back into Libertadores. With those five I also get a lot of knowledge about Champions and Europa League, and Libertadores and Sudamericana. Anything more, and I'm putting in too much work to follow each well.
Finally, I have a power rating system for each league, and use third-party ratings for European and South American international play to narrow my picks. I pretty much go strictly by power ratings unless I read something that would tell me those numbers are skewed.