Indy played in Buf two years ago, one week earlier than this. They romped. I was there to enjoy it.
Now, here's a (bullshit) system play for you .. I live about an hour north of Buffalo and make a point of going to at least two games per year and have been doing so for the past six years. I have never ever ever seen Buffalo win. I was at the game last week vs. the Texans, and I am happy to report that I officially think I am some kind of Bills jinx (which is perfect because I hate them more than the Cowboys.) I will be attending this week's game as well, and see no reason why 'Tanya the jinx' won't prove to be a fair play.
Of course I'm being a jackass, but I think it is safe to say that Indy will win this one by 10 points, at least.