It is odd that the Bolts are favored, but I don't see them winning no matter how many stats you throw at me.
I think both teams will go nuts and put up points. Peyton Manning is looking insane again and maybe Marvin Harrison is finally breaking out of his funk. A hot Manning will rip apart the Bolts secondary. Also, Addai is becoming a pretty big threat now. SD should put up points, but if it turns into a shootout, then the Colts win.
Two teams going in opposite directions this late into the season, one team looks poised to make the playoffs now, while the other seems to want the season to finish ASAP.
Also, Norv Turner... need I say more?