Yes it is:
1)1st place teams getting drawn against 2nd place teams for knock-out round
2) 1st place has home-game in 2nd leg, which is an advantage
3)
Expected outcome:
1st: Liverpool, Barca, Milan, Lyon, Inter, Villareal/Mu, Arsenal
2nd: Chelsea, Udinese, PSV, Real, Rangers, MU/Lille, Ajax
Besides Chelsea the second place teams are definetely easier to play IMO
BTW 3rd place is going to uefa-cup and is out of champions league