Mad, listen well. The reason why it don't matter what you're laying is because if you find a game that you handicapped and see it has a better than 62% chance of winning, and you are laying -160, then it's worth it to lay it. If you find a game that according to you, will win 75% of the time, and you are laying -260, play it.. You will end up a winner. The juice has NOTHING to do with winning or losing, it's all in the value.
Would you lay -2200 on an NBA game. Probably not right? But what if that game happens to be the Lakers at home and they are a 23.5 point favorite and all they have to do is win outright and not cover. Wouldn't laying 2200 become a good bet because they will win outright a good 96% of the time, which would show a profit.
Remember, what you lay or take has nothing to do with being a good bet or not. If that line is off according to your numbers, then bet it...